《绝望的主妇》第五季是跳跃到了五年后。五年后的紫藤街将又是一番如何景象? Katherine终于正式成为第六位主妇。Bree成了家政女王,她与Orson复合的前因后果会在第五季第1集揭晓;Gaby也成了妈,成了肥肥的黄脸婆;Susan将会有新男人;孩子不听话,Lynette焦头烂额;Eddie将会带上新男人和新秘密重返紫藤街。 新加盟的男演员Neal McDonough带来了新的神秘感,成为Eddie的新男人;Gale Harold(曾主演知名剧《同志亦凡人》)也将出演 Susan的新男人。Gaby的盲人丈夫Carlos在本季稍后将会复明!而这一重大转折将促使夫妇俩来个彻头彻尾的改变。据说会动用到整容医生。难道 Gaby就是这样戏剧性地从肥胖的黄脸婆回归到光鲜的? 这一切都将发生在《绝望的主妇》第五季中。The story of the ladies on Wisteria Lane are moved ahead five years in time to when Susan flirts with her painter, Jackson Braddock, after Mike having been gone for so long, but not willing to commit to a relationship. Meanwhile, Bree denies all the help "her" company has received from her business partner Katherine, while Andrew feels like a doormat under Bree's influence. Lynette still has problems in getting Tom to see the light when it comes to their over exuberant trouble-making twins Porter and Preston. Also, Edie moves back to Wisteria Lane with a new husband: a charming but mysterious guy named Dave Williams who no one knows anything about. Elsewhere, Gabrielle deals with Carlos who is still blind as well as their two spoiled and overweight daughters Juanita and Celia.