影片由加拿大演员、歌手罗伯·斯代法钮克自导自演,Alice Cooper、Iggy Pop、Carol Pope、Henry Rollins以及Moby等众多大牌客串。斯代法钮克饰演的乔伊是新人乐队The Winners的主唱。女贝斯手詹妮弗(杰西卡·派尔)在同一名吸血鬼一夜情之后拥有了神奇的性感魅力,使得乐队瞬间征服台下的所有观众。The Winners成名在望,然而名为Eddie Van Helsing(马尔科姆·麦克道威尔)的吸血鬼猎人在他们身后紧追不舍。In Montreal, Joey is the lead singer of the struggling band "The Winners", composed by the sexy bass singer Jennifer, the guitarist Tyler, the drummer Sam and the handyman Hugo. Their incompetent and alcoholic manager Jeff is incapable to help them to reach success and they are on the road on tour playing in clubs and bars in Canada and United States of America. After a show in a bar in Montreal, Jennifer, who is also the Joey's former girlfriend, leaves the place with the creepy Queeny, who is a vampire, and they spend the night together. On the next morning, Jennifer does not meet the band and they travel in their hearse to participate in a rock 'n' roll show without her. In the last moment, Jennifer arrives with a different appearance and on the next day they find that their home page had had several hits, all of them with good reviews and compliments to Jennifer. They become famous and Jennifer great audiences to the shows of "The Winners" and one by one, the musicians are turned into vampires but the reluctant Joey. "The Winners" become successful and Joey has a dream where he meets the bartender (Alice Cooper) of their show in Montreal in a crossroad and the man tells that he needs to decide whether he wants to be a winner or a loser. Meanwhile the vampire hunter Eddie Van Helsing is hunting the vampire queen and tracking "The Winners" in their shows.